[chris_tribble]

I have the Domke F803 Satchel + a slightly modified 720-220 insert (it's too tall normally + there's no velcro on the long sides - easy to adapt if you have access to a sewing machine)

I regularly carry TWO bodies (each with a lens on) + 4 extra lenses. Typical set up is:
M8 + 35 f2
M8 + 28 f2
CV 16 + 135 Apo Telyt
21 f2.8 + 75 Asph

I can also carry a Frankenfinder + SF20 in one pocket + spare caps and flashlight in 'tother + 2 spare batteries + 4 SD cards and cleaning cloth in the flap pockets. Passport + tickets go in the back of the bag when on the road.

Works fine - beats carrying around the DSLR setup!