[Jack_Flesher]

First, the above comments re exposure are right on the mark -- But assuming you get that under control, for lower ISO images, 160 and 320:

In C1 try checking the box for "pattern noise supression" and keep sharpening on, but at a low level, like soft look around 100, threshold 4 to keep from accentuating noise.

In ACR try these: set sharpening to 15, radius 1, detail 15 and masking to 0. Under noise reduction set luminance to 10 and color to 25.

The files that now enter CS may look a bit soft, but *if* sharpened properly there, should exhibit excellent detail without any objectional artifacts and handle up-rezznig to 400% native size easily.

Cheers,